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A framework for aiding future Java mutation tool comparisons. 

Proper statistical modeling incorporates domain theory about how concepts relate and details of how data were measured. However, data analysts currently lack tool support for recording and reasoning about domain assumptions, data collection, and modeling choices in an integrated manner, leading to mistakes that can compromise scientific validity. For instance, generalized linear mixed-effects models (GLMMs) help answer complex research questions, but omitting random effects impairs the generalizability of results. To address this need, we present Tisane, a mixed-initiative system for authoring generalized linear models with and without mixed-effects. Tisane introduces a study design specification language for expressing and asking questions about relationships between variables. Tisane contributes an interactive compilation process that represents relationships in a graph, infers candidate statistical models, and asks follow-up questions to disambiguate user queries to construct a valid model. In case studies with three researchers, we find that Tisane helps them focus on their goals and assumptions while avoiding past mistakes. 

Data analysis requires translating higher level questions and hypotheses into computable statistical models. We present a mixed-methods study aimed at identifying the steps, considerations, and challenges involved in operationalizing hypotheses into statistical models, a process we refer to as hypothesis formalization . In a formative content analysis of 50 research papers, we find that researchers highlight decomposing a hypothesis into sub-hypotheses, selecting proxy variables, and formulating statistical models based on data collection design as key steps. In a lab study, we find that analysts fixated on implementation and shaped their analyses to fit familiar approaches, even if sub-optimal. In an analysis of software tools, we find that tools provide inconsistent, low-level abstractions that may limit the statistical models analysts use to formalize hypotheses. Based on these observations, we characterize hypothesis formalization as a dual-search process balancing conceptual and statistical considerations constrained by data and computation and discuss implications for future tools.